Rua de Francisco Xavier Pereira that begins at Estrada do Repouso in the south and ends at Avenida de Venceslau de Morais in the north runs through two parishes,  Parish of Santo António and Parish of Nossa Senhora de Fátima.

The street was completed on 22 January, 1919 and it was officially named after Francisco Xavier Pereira, who was the youngest president of the Municipal Council.

Amongst the blocks of buildings and structures that stretch from south to north of the street are St. Francis Xavier Church (built in 1907 in commemoration of the famous missionary, S. Francisco Xavier), S. Francis Xavier Home for the Aged and the new campus of the primary levels of Keang Peng School.
. A row of villas built in the 1940s stands along the street where TDM - Teledifusão de Macau is located. These well-preserved buildings are a rare historic landmark of the city.